ABOUT TRAMADOL (RETARD)

Opioid exercise is because of each lower affinity binding in the father or mother compound and better affinity binding in the O-demethylated metabolite M1 to μ-opioid receptors. In animal models, M1 is nearly 6 times additional powerful than tramadol in generating analgesia and two hundred instances far more powerful in μ-opioid binding.Emphasize